Three months ended
March 31,
|
||||||||||||
Notes
|
2023
£’000
|
2022
£’000
|
||||||||||
Product revenue, net
|
3
|
42,052
|
7,682
|
|||||||||
Pre-product revenue, net
|
3
|
—
|
2,829
|
|||||||||
Total revenue from sales of therapies
|
42,052
|
10,511
|
||||||||||
Collaboration revenue
|
3
|
2,489
|
11,963
|
|||||||||
Total revenue
|
44,541
|
22,474
|
||||||||||
Cost of product revenue
|
(178
|
)
|
(248
|
)
|
||||||||
Research and development costs
|
(28,449
|
)
|
(18,581
|
)
|
||||||||
Selling and administrative expenses
|
4
|
(33,301
|
)
|
(20,105
|
)
|
|||||||
Operating loss
|
(17,387
|
)
|
(16,460
|
)
|
||||||||
Finance income
|
5
|
2,546
|
10
|
|||||||||
Finance costs
|
(1,620
|
)
|
(1,333
|
)
|
||||||||
Net finance income / (costs)
|
926
|
(1,323
|
)
|
|||||||||
Loss before taxation
|
(16,461
|
)
|
(17,783
|
)
|
||||||||
Income tax (charge) / credit
|
6
|
(236
|
)
|
1,655
|
||||||||
Loss for the period
|
(16,697
|
)
|
(16,128
|
)
|
||||||||
Other comprehensive income
|
||||||||||||
Other comprehensive income that is or may be reclassified to profit or loss in subsequent periods:
|
||||||||||||
Exchange differences on translation of foreign operations
|
380
|
205
|
||||||||||
Total other comprehensive income for the period
|
380
|
205
|
||||||||||
Total comprehensive loss for the period
|
(16,317
|
)
|
(15,923
|
)
|
||||||||
Basic and diluted loss per share - £
|
7
|
(0.35
|
)
|
(0.37
|
)
|
Notes
|
March 31,
2023
£’000
|
December 31,
2022
£’000
|
||||||||||
Non-current assets
|
||||||||||||
Property, plant and equipment
|
8
|
8,156
|
6,472
|
|||||||||
Intangible assets
|
410
|
410
|
||||||||||
Right of use assets
|
24,742
|
25,173
|
||||||||||
Other non-current assets
|
7,033
|
7,342
|
||||||||||
Deferred tax asset
|
6
|
4,285
|
4,240
|
|||||||||
Total non-current assets
|
44,626
|
43,637
|
||||||||||
Current assets
|
||||||||||||
Inventory
|
882
|
943
|
||||||||||
Trade and other receivables
|
9
|
45,200
|
46,711
|
|||||||||
Tax receivable
|
6
|
2,365
|
11,688
|
|||||||||
Cash and cash equivalents
|
337,461
|
332,539
|
||||||||||
Total current assets
|
385,908
|
391,881
|
||||||||||
Total assets
|
430,534
|
435,518
|
||||||||||
Equity
|
||||||||||||
Share capital
|
10
|
97
|
97
|
|||||||||
Share premium
|
128,744
|
123,751
|
||||||||||
Foreign currency translation reserve
|
(2,717
|
)
|
(3,097
|
)
|
||||||||
Other reserves
|
337,847
|
337,847
|
||||||||||
Share-based payment reserve
|
11
|
88,072
|
81,411
|
|||||||||
Accumulated deficit
|
(277,950
|
)
|
(261,253
|
)
|
||||||||
Total equity
|
274,093
|
278,756
|
||||||||||
Non-current liabilities
|
||||||||||||
Non-current accruals
|
824
|
1,479
|
||||||||||
Interest-bearing loans and borrowings
|
38,677
|
39,500
|
||||||||||
Deferred revenue
|
3
|
4,331
|
4,331
|
|||||||||
Lease liabilities
|
27,822
|
28,248
|
||||||||||
Provisions
|
125
|
114
|
||||||||||
Total non-current liabilities
|
71,779
|
73,672
|
||||||||||
Current liabilities
|
||||||||||||
Trade and other payables
|
12
|
78,158
|
75,076
|
|||||||||
Deferred revenue
|
3
|
4,806
|
6,408
|
|||||||||
Lease liabilities
|
1,636
|
1,555
|
||||||||||
Provisions
|
62
|
51
|
||||||||||
Total current liabilities
|
84,662
|
83,090
|
||||||||||
Total liabilities
|
156,441
|
156,762
|
||||||||||
Total equity and liabilities
|
430,534
|
435,518
|
Notes
|
Share
capital
£’000
|
Share
premium
£’000
|
Foreign
currency
translation
reserve
£’000
|
Share-
based
payment
reserve
£’000
|
Other
reserve
£’000
|
Accumulated
deficit
£’000
|
Total
equity
£’000
|
|||||||||||||||||||||||||
At January 1, 2023
|
97
|
123,751
|
(3,097
|
)
|
81,411
|
337,847
|
(261,253
|
)
|
278,756
|
|||||||||||||||||||||||
Loss for the period
|
—
|
—
|
—
|
—
|
—
|
(16,697
|
)
|
(16,697
|
)
|
|||||||||||||||||||||||
Other comprehensive income
|
—
|
—
|
380
|
—
|
—
|
—
|
380
|
|||||||||||||||||||||||||
Total comprehensive loss for the period
|
—
|
—
|
380
|
—
|
—
|
(16,697
|
)
|
(16,317
|
)
|
|||||||||||||||||||||||
Exercise of share options
|
11
|
—
|
4,993
|
—
|
—
|
—
|
—
|
4,993
|
||||||||||||||||||||||||
Equity-settled share-based payment transactions
|
11
|
—
|
—
|
—
|
6,661
|
—
|
—
|
6,661
|
||||||||||||||||||||||||
At March 31, 2023
|
97
|
128,744
|
(2,717
|
)
|
88,072
|
337,847
|
(277,950
|
)
|
274,093
|
Notes
|
Share
capital
£’000
|
Share
premium
£’000
|
Foreign
currency
translation
reserve
£’000
|
Share-
based
payment
reserve
£’000
|
Other
reserve
£’000
|
Accumulated
deficit
£’000
|
Total
equity
£’000
|
|||||||||||||||||||||||||
At January 1, 2022
|
88
|
212,238
|
89
|
54,357
|
386,167
|
(481,392
|
)
|
171,547
|
||||||||||||||||||||||||
Loss for the period
|
—
|
—
|
—
|
—
|
—
|
(16,128
|
)
|
(16,128
|
)
|
|||||||||||||||||||||||
Other comprehensive income
|
—
|
—
|
205
|
—
|
—
|
—
|
205
|
|||||||||||||||||||||||||
Total comprehensive loss for the period
|
—
|
—
|
205
|
—
|
—
|
(16,128
|
)
|
(15,923
|
)
|
|||||||||||||||||||||||
Exercise of share options
|
11
|
—
|
261
|
—
|
—
|
—
|
—
|
261
|
||||||||||||||||||||||||
Equity-settled share-based payment transactions
|
11
|
—
|
—
|
—
|
7,413
|
—
|
—
|
7,413
|
||||||||||||||||||||||||
At March 31, 2022
|
88
|
212,499
|
294
|
61,770
|
386,167
|
(497,520
|
)
|
163,298
|
Three Months Ended
March 31,
|
||||||||||||
Notes
|
2023
£’000
|
2022
£’000
|
||||||||||
Cash flows from operating activities
|
||||||||||||
Loss for the period
|
(16,697
|
)
|
(16,128
|
)
|
||||||||
Adjustments for:
|
||||||||||||
Equity settled share-based payment expense
|
11
|
6,661
|
7,413
|
|||||||||
Depreciation
|
1,285
|
1,679
|
||||||||||
Net finance (income) / costs
|
(926
|
)
|
1,323
|
|||||||||
Foreign exchange movements
|
5,725
|
945
|
||||||||||
Other
|
(18
|
)
|
(1
|
)
|
||||||||
Income tax charge / (credit)
|
6
|
236
|
(1,655
|
)
|
||||||||
Working capital adjustments:
|
||||||||||||
Decrease / (increase) in receivables and other non-current assets
|
2,852
|
(11,489
|
)
|
|||||||||
Increase / (decrease) in trade and other payables
|
2,111
|
(807
|
)
|
|||||||||
Decrease in deferred revenue
|
(1,602
|
)
|
(11,633
|
)
|
||||||||
Other working capital movements
|
(562
|
)
|
(480
|
)
|
||||||||
Cash used in operations
|
(935
|
)
|
(30,833
|
)
|
||||||||
Taxation received
|
6
|
9,904
|
—
|
|||||||||
Taxation paid
|
6
|
(177
|
)
|
—
|
||||||||
Net cash from / (used in) operating activities
|
8,792
|
(30,833
|
)
|
|||||||||
Cash flows from investing activities
|
||||||||||||
Proceeds from sale of property, plant and equipment
|
—
|
5
|
||||||||||
Purchase of property, plant and equipment
|
8 |
(2,470
|
)
|
(138
|
)
|
|||||||
Interest received
|
2,076
|
—
|
||||||||||
Net cash flows used in investing activities
|
(394
|
)
|
(133
|
)
|
||||||||
Cash flows from financing activities
|
||||||||||||
Exercise of share options
|
11
|
4,993
|
261
|
|||||||||
Interest paid
|
(2,101
|
)
|
(838
|
)
|
||||||||
Repayment of lease liabilities
|
(407
|
)
|
(755
|
)
|
||||||||
Net cash flows from / (used in) financing activities
|
2,485
|
(1,332
|
)
|
|||||||||
Increase / (decrease) in cash and cash equivalents
|
10,883
|
(32,298
|
)
|
|||||||||
Net foreign exchange difference on cash held
|
(5,961
|
)
|
265
|
|||||||||
Cash and cash equivalents at beginning of the period
|
332,539
|
237,886
|
||||||||||
Cash and cash equivalents at end of the period
|
337,461
|
205,853
|
For the three months ended
March 31,
|
||||||||
2023
£’000
|
2022
£’000
|
|||||||
Product revenue, net
|
42,052
|
7,682
|
||||||
Pre-product revenue, net
|
—
|
2,829
|
||||||
Total revenue from sale of therapies
|
42,052
|
10,511
|
||||||
Collaboration revenue
|
||||||||
Eli Lilly
|
—
|
7,361
|
||||||
Genentech
|
2,489
|
4,602
|
||||||
Total collaboration revenue
|
2,489
|
11,963
|
||||||
Total revenue
|
44,541
|
22,474
|
For the three months ended
March 31,
|
||||||||
2023
£’000
|
2022
£’000
|
|||||||
United States
|
29,533
|
7,682
|
||||||
Europe
|
12,328
|
2,829
|
||||||
Rest of the World
|
191
|
—
|
||||||
Total revenue from the sale of therapies
|
42,052
|
10,511
|
For the three months ended
March 31,
|
||||||||
2023
|
2022
|
|||||||
Loss for the period (£’000s)
|
(16,697
|
)
|
(16,128
|
)
|
||||
Basic and diluted weighted average number of shares
|
48,183,771
|
43,865,799
|
||||||
Basic and diluted loss per share (£)
|
(0.35
|
)
|
(0.37
|
)
|
March 31,
2023
£’000
|
December 31,
2022
£’000
|
|||||||
Trade receivables
|
30,164
|
27,736
|
||||||
Other receivables
|
3,015
|
7,682
|
||||||
Prepayments and accrued income
|
12,021
|
11,293
|
||||||
45,200
|
46,711
|
Issued and fully paid share capital
|
Ordinary
|
Deferred
|
||||||
(0.2p per share, except deferred shares which are 0.01p per share)
|
shares
|
shares
|
||||||
At January 1, 2023
|
48,088,346
|
5,793,501
|
||||||
Exercise of share options
|
291,063
|
—
|
||||||
At March 31, 2023
|
48,379,409
|
5,793,501
|
For the three months ended
March 31
|
||||||||
|
2023
$
|
2022
$
|
||||||
Weighted average exercise price
|
64.39
|
24.95
|
||||||
Weighted average fair value
|
39.83
|
15.27
|
March 31,
2023
£’000
|
December 31,
2022
£’000
|
|||||||
Trade payables
|
9,333
|
11,716
|
||||||
Corporation tax liability
|
423
|
—
|
||||||
Other taxation and social security
|
1,482
|
927
|
||||||
Pension liability
|
221
|
34
|
||||||
Accruals
|
66,699
|
62,399
|
||||||
78,158
|
75,076
|